The following is a list of individuals associated with Hampshire College through attending as a student, or serving as a member of the faculty or staff.

• Bram Cohen, original author and developer of BitTorrent
• Matthew Cook, group leader at the Institute for Neuroinformatics at ETH Zurich and computer scientist who proved the Turing universality of Wolfram's Rule 110 cellular automaton
• Lenore Cowen, computer scientist and mathematician at Tufts University
• Alan Edelman, professor of mathematics at the Massachusetts Institute of Technology
• Alan Grayson, former member of the U.S. House of Representatives (D-Florida)
• Neil Immerman, professor of computer science at the University of Massachusetts Amherst
• Susan Landau, professor of cybersecurity and policy at Tufts University, visiting scholar of computer science at Harvard University, Guggenheim Fellow
• Eric Lander, mathematician and geneticist, professor of biology at the Massachusetts Institute of Technology and science advisor to President Barack Obama, MacArthur Fellow
• Adam Marcus, professor of mathematics at Princeton University
• Cathy O'Neil, data scientist and blogger at Mathbabe, Director of the Lede Program in Data Practices at Columbia University
• Jim Propp, professor of mathematics at the University of Massachusetts Lowell
• Dana Randall, professor of computer science at Georgia Tech
• Lisa Randall, Frank B. Baird, Jr. Professor of Science at Harvard University, known for developing the Randall–Sundrum model
• Seth Schoen, technologist at the Electronic Frontier Foundation
• Steven Strogatz, Professor of Applied Mathematics at Cornell University
• Eugene Volokh,^[7] Gary T. Schwartz Professor of Law at UCLA Law School, scholar of American constitutional law and libertarianism
• Erik Winfree, professor of computer science and bioengineering at the California Institute of Technology, MacArthur Fellow

• Franklin Patterson (1966–1971), first president of Hampshire College and co-author of the New College Plan
• Charles R. Longsworth (1971–1977), current director of Saul Centers, Inc., former President, CEO, and Chairman of The Colonial Williamsburg Foundation
• Adele S. Simmons (1977–1989), former President of the MacArthur Foundation and first female dean of student affairs at Princeton University
• Gregory S. Prince, Jr. (1989–2005), chairman of the Association of Independent Colleges and Universities in Massachusetts and vice-chair of the Council on Racial and Ethnic Justice of the American Bar Association
• Ralph J. Hexter (2005–2010), former dean at UC Berkeley and Acting Chancellor of UC Davis, founding member of LGBTQ Presidents in Higher Education
• Marlene Gerber Fried (2010–2011) (interim)
• Jonathan Lash (2011–2018), attorney, member of the board of directors and former president of the World Resources Institute
• Miriam E. Nelson (2018–2019), acting president and CEO of Newman's Own Foundation, best-selling author, and nutritionist
• Kenneth Rosenthal (2019) (interim)
• Edward Wingenbach (2019–present), former acting president of Ripon College