2014

• October 28: The Cygnus Orb-3 cargo spacecraft fails to orbit after its Antares rocket explodes. An uncontained failure in one of the rocket's NK-33 first stage engines caused the vehicle to collapse back on the launch pad, destroying the rocket, spacecraft, and cargo, as well as causing significant damage to the launch complex. No personnel were injured in the incident.

2015

• June 28: The SpaceX CRS-7 Dragon cargo spacecraft fails to orbit after its Falcon 9 rocket disintegrates 139 seconds in flight. A helium COPV on the second stage had broken free of its mounting point, causing an overpressure event that burst the second stage; the Dragon spacecraft and rocket debris impacted the ocean moments later and were destroyed. An investigation traced the fault to a defective stainless steel bolt that failed at one-fifth of its design load, which SpaceX did not properly qualify for performance under cryogenic temperatures. An International Docking Adapter necessary for future American crew flights to the space station was among the cargo lost, a replacement was manufactured from spare components.^[1]

2018

• August 29: An air leak caused by a 2 mm hole is discovered in the docked Soyuz MS-09 spacecraft. Astronauts initially patched the leak with Kapton tape, and later sealed with an epoxy patch.^[2] Russian officials accused NASA astronaut Serena Auñón-Chancellor of boring the hole, a claim described by Ars Technica as "preposterous" and "a complete fabrication".^[3]

  

• October 11: The Soyuz MS-10 crew mission fails to orbit after its booster disintegrates in flight. Astronauts Aleksey Ovchinin and Nick Hague are saved by the spacecraft's launch escape system, and land 402 km (250 mi) downrange in Kazakhstan.^[4]

2019

• April 20: A SpaceX Dragon crew capsule exploded during ground testing of its launch abort system. The delay injured no personnel but resulted in delays to timelines of the spacecraft's first crewed flight.^[5]
• August 23: News media report on an incident where astronaut Anne McClain is accused of illegally accessing her divorced spouse Summer Worden's bank accounts while on board the station. The accusations were false and Worden was later indicted for lying to authorities.^[6][7]
• December 20: The Boeing Orbital Flight Test, an uncrewed flight test of the Boeing Starliner crew spacecraft, is successfully launched but experiences several technical issues in orbit related to an erroneously configured mission timer. The planned docking attempt to the ISS was called off and the spacecraft landed in New Mexico two days later.^[8] Boeing would conduct a repeat mission on its own funds two years later.^[9]

2021

• July 29: The recently docked Nauka space station module experienced a computer glitch that caused it to fire its thrusters, causing the space station to be rotated end-over-end one and a half times; a "spacecraft emergency" was called for the first time in the history of the program by flight director Zebulon Scoville.^[10] Attitude control was only regained after the errant module had completely depleted its fuel reserves. The module had experienced technical issues related to its propulsion prior to docking with the ISS. The uncrewed Boe-OFT2 Starliner mission would be delayed 96 hours due to the incident, but later would be cancelled entirely after the Starliner's valves were found to be faulty.^[11]
• November 15: Russia conducts an anti-satellite missile test and shatters the Kosmos 1408 spacecraft into a cloud of thousands of debris fragments, endangering the International Space Station and other spacecraft. All crew aboard the ISS were ordered to don spacesuits and proceed to their respective return spacecraft in the event that the ISS were to be struck by debris and depressurized.^[12] In June 2022, the space station executed a maneuver to dodge a debris fragment from the destroyed satellite.^[13]

2022

• May 19: The Boeing Orbital Flight Test 2, a repeat of a previous abortive Starliner test flight, successfully docked with the space station but not without incident. Two of the spacecraft's maneuvering thrusters failed prior to the docking, which did not end up causing any issues with the mission.^[14]

• December 14: Soyuz MS-22 spacecraft sprung a leak in external cooling loop of the service module. The leak was determined to be caused by a micrometeoroid impact. The spacecraft stayed docked as an emergency rescue vehicle but was deemed not viable for a normal crew return. As a result, Soyuz MS-23 was launched without crew as a replacement in February, while MS-22 undocked and landed without the crew on March 28. ^[15] The mission of the crew was extended and they returned on September 27th on Soyuz MS-23, setting the record of the longest US spaceflight.

2023

• February 11: Progress MS-21 spacecraft sprung a leak in external cooling loop of the service module. The leak was determined to be caused by a micrometeoroid impact. The leak area was inspected using Canadarm2 as well as photographs taken after undocking. The incident resulted in a delay of Soyuz MS-23 launch, needed to replace Soyuz MS-22 that had a leak several months prior. ^[16]
• October 9: A leak from one of Nauka Multipurpose Laboratory Module radiators was observed with the ISS cameras and visual inspections. The origin of the leak was Nauka’s backup radiator while the primary radiator continued working as normal. The radiator system was first delivered to the ISS in 2010 and installed in April 2023. As a result of the incident, the two NASA spacewalks have been postponed. ^[17] During Roscosmos spacewalk on October 25 the backup radiator was isolated and inspected. During inspection a bubble of coolant liberated from the leak area, causing additional precautions at the end of the spacewalk to avoid contaminating the ISS environment. ^[18]

2024

• March 8: A 0.7 kilograms (1.5 lb) piece of space junk that survived reentry has impacted a house in Naples, Florida. No people were harmed. NASA later confirmed the object to be an inconel stanchion that was a part of a cargo pallet with old batteries jettisoned from the ISS in March 2021. ^[19] The pallets were originally planned to be safely disposed of with an HTV spacecraft that delivered the replacement batteries to the space station, but Exposed Pallet brought by HTV-7 was left on the ISS due to Soyuz MS-10 launch failure affecting spacewalk schedules. After the final HTV flight one pallet remained on the ISS, and it was jettisoned from the ISS after being estimated to burn up completely on reentry. ^[20]