The United States ambassador to Saint Kitts and Nevis (or, prior to August 3, 1988, to Saint Christopher and Nevis) is the official representative of the government of the United States to the government of Saint Kitts and Nevis. The title of the ambassador is United States Ambassador to Barbados and the Eastern Caribbean and is concurrently the ambassador to Antigua and Barbuda, Barbados, Dominica, Grenada, St. Lucia, and St. Vincent and the Grenadines.

The United States established diplomatic relations with Saint Christopher and Nevis on September 20, 1983, but no U.S. mission has ever been established at Basseterre. After June 25, 1988, all relations were handled by the Embassy at St. John's, Antigua and Barbuda. When that Embassy closed on June 30, 1994, all diplomatic functions have been handled out of the U.S. Embassy at Bridgetown, Barbados, where the U.S. Ambassador to Saint Kitts and Nevis is resident.

The following is a list of U.S. ambassadors, or other chiefs of mission, to Saint Kitts and Nevis. The title given by the United States State Department to this position is currently Ambassador Extraordinary and Plenipotentiary.

• Saint Kitts and Nevis – United States relations
• Foreign relations of Saint Kitts and Nevis
• Ambassadors of the United States