The following list sorts all cities and communes in the German state of Lower Saxony with a population of more than 25,000.^[1] As of December 31, 2017, 63 cities fulfill this criterion and are listed here. This list refers only to the population of individual municipalities within their defined limits, which does not include other municipalities or suburban areas within urban agglomerations.

The following table lists the 63 cities and communes in Lower Saxony with a population of at least 25,000 on December 31, 2017, as estimated by the Federal Statistical Office of Germany.^[2] A city is displayed in bold if it is a state or federal capital.

1. The city rank by population as of December 31, 2017, as estimated by the Federal Statistical Office of German^[2]
2. The city name^[2]
3. The name of the district (Landkreis) in which the city lies (some cities are districts on their own called urban districts)^[2]
4. The city population as of December 31, 2017, as estimated by the Federal Statistical Office of Germany^[2]
5. The city population as of May 9, 2011, as enumerated by the 2011 European Union census^[3]
6. The city land area as of December 31, 2017^[2]
7. The city population density as of December 31, 2017 (residents per unit of land area)^[2]

• Cities in Lower Saxony by population