This is a list of mayors of the 50 largest cities in the United States, ordered by their populations as of July 1, 2022, as estimated by the United States Census Bureau.^[1][2] These 50 cities have a combined population of 49.6 million, or 15% of the national population.

Honolulu, Indianapolis, Jacksonville, Louisville, and Nashville have consolidated city-county governments where the mayor is elected by residents of the entire county, not just that of the main city; in these cases the population and respective rank are for the county.

In some states, mayors are officially elected on a nonpartisan basis; however, their party affiliation or preference is generally known, and where it is known it is shown in the list below.

The breakdown of mayoral political parties is 36 Democrats, 10 Republicans, and 4 Independents (two elected with state Democratic support).

• List of longest-serving mayors in the United States
• List of United States cities by population
• Mayoralty in the United States
• United States Conference of Mayors