The city of Toledo, Ohio, the largest city and the county seat of Lucas County, Ohio, is the birthplace and home of several notable individuals. This is a list of people from Toledo, Ohio and includes people that were born or lived in Toledo, Ohio and the surrounding area. Individuals included in this listing are people presumed to be notable because they have received significant coverage in reliable sources that are independent of the subject.

• Stephen Bolles – U.S. Representative from Wisconsin
• Walter Folger Brown – former Postmaster General of the United States
• Doug Ducey – Arizona Secretary of the Treasury, then Governor
• Ernest E. Debs – Los Angeles City Council member and county supervisor, born in Toledo
• Thomas Francis Ford – member of the U.S. Congress, elected to Los Angeles City Council by write-in vote
• Samuel M. Jones – Mayor 1897-1904
• Marcy Kaptur – U.S. Representative for Ohio's 9th congressional district
• Kristina Keneally – Premier of New South Wales, Australia
• Daniel Poneman – former U.S. Deputy Secretary of Energy
• Natalie Price – member of the Michigan House of Representatives
• Stephanie Rader – OSS spy in WWII
• Jason Sheppard – member of the Michigan House of Representatives^[6]
• Brand Whitlock – Mayor and U.S. Ambassador to Belgium during World War I

• Doug Dohring – former CEO and co-founder of Neopets
• Martin Frankel – former financier convicted in 2002 of insurance fraud, racketeering and money laundering
• Edward Drummond Libbey – glassmaker, philanthropist

• Eugene F. "Gene" Kranz – retired NASA flight director who served during the Gemini and Apollo space programs, known for his role in the rescue of Apollo 13
• Lyman Spitzer Jr. – theoretical physicist, astronomer, driving force behind the Hubble Space Telescope
• Michael S. Witherell – particle physicist, former director of Fermilab, and presently director of Lawrence Berkeley National Laboratory
• Jeff Kummer - Discovered the human bodies Inner-Radial Magnetism.

• Henry Noble MacCracken – longtime president of Vassar College, a founder of Sarah Lawrence College
• Ernest M. McSorley – captain of the ill-fated lake freighter SS Edmund Fitzgerald
• Selma Rubin – environmental activist based in Santa Barbara, California
• Rosa L. Segur – suffragist
• Ella P. Stewart – pharmacist (one of the first black female pharmacists in the United States), civic leader, and philanthropist.

• List of mayors of Toledo, Ohio
• List of people from Ohio