Louis de Bourbon (October 1612 – 6 August 1669), was Duke of Mercœur and later the second Duke of Vendôme, and the grandson of Henry IV of France and Gabrielle d'Estrées. He became Duke of Vendôme in 1665, after the death of his father.

Louis was the son of César de Bourbon, Légitimé de France, Duke of Vendôme and Françoise de Lorraine (1592–1669), daughter of Philippe Emmanuel, Duke of Mercœur (d. 1602).^[1] Louis had a military career and was Governor of Provence from 1653 to 1669. After the death of his wife in 1657, he entered the church and became a cardinal and legate of France.^[1] As a cardinal, he was styled as the cardinal de Vendôme.^[2]

Louis married Laura Mancini, niece of Cardinal Mazarin, on 4 February 1651.^[3] Their children:

• Louis Joseph de Bourbon (1654–1712), Duke of Vendôme and Marshal of France; married Marie Anne de Bourbon^[2] no issue;
• Philippe de Bourbon (1655–1727), called le prieur de Vendôme, last Duke of Vendôme; never married; no issue.^[2]
• Jules César de Bourbon (1657–1660) died in infancy.

• Pavillon Vendôme