Louis Holmes (February 24, 1985 – June 13, 2023) was an American football defensive end. He was signed by the San Francisco 49ers as an undrafted free agent in 2008. He played college football at Arizona.

He spent final prep season at Dillard High School (Fort Lauderdale, FL) after attending his first three years of high school in his hometown of Memphis.

Holmes totaled 265 tackles, 22.0 sacks and 50.5 tackles for loss in four collegiate seasons, spending first two years at Scottsdale Community College before transferring to the University of Arizona for his final two campaigns. He played in 12 games with 10 starts for Arizona as a senior in 2007, tallying 37 tackles, two sacks and 5.5 tackles for loss. He was named Second-team All-Pac-10 during first season at Arizona as a junior, recording 36 tackles, four sacks, five tackles for loss, two forced fumbles and one fumble recovery. He combined for 192 tackles, 16.0 sacks and 40 tackles for loss in two seasons at Scottsdale Community College, garnering NJCAA All-American, All-Regional and All-Western States Football League honors.^[1]