MESP1

MESP1
Identifiers
Aliases	MESP1, bHLHc5, mesoderm posterior bHLH transcription factor 1
External IDs	OMIM: 608689 MGI: 107785 HomoloGene: 32039 GeneCards: MESP1
Gene location (Human)
Chr.	Chromosome 15 (human)
End	89,751,249 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	79,443,536 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; prefrontal cortex; ; amygdala; ; cingulate gyrus; ; gastrocnemius muscle; ; Brodmann area 9; ; middle temporal gyrus; ; prostate; ; hypothalamus;
	Top expressed in
	seminiferous tubule; ; spermatocyte; ; spermatid; ; primitive streak; ; right ventricle; ; submandibular gland; ; morula; ; allantois; ; mesoderm; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein dimerization activity; DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	Notch signaling pathway; neurogenesis; cardiac ventricle formation; regulation of transcription, DNA-templated; lateral mesoderm development; positive regulation of hepatocyte differentiation; positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway; negative regulation of mesodermal cell fate specification; cardiac muscle cell differentiation; positive regulation of Notch signaling pathway involved in heart induction; cardiac vascular smooth muscle cell differentiation; signal transduction involved in regulation of gene expression; heart morphogenesis; transcription by RNA polymerase II; transcription, DNA-templated; sinus venosus morphogenesis; heart looping; positive regulation of transcription, DNA-templated; cardioblast migration; cardiac cell fate determination; multicellular organism development; gastrulation; embryonic heart tube morphogenesis; growth involved in heart morphogenesis; positive regulation of striated muscle cell differentiation; cardioblast migration to the midline involved in heart field formation; endothelial cell differentiation; sinoatrial node cell differentiation; negative regulation of endodermal cell fate specification; secondary heart field specification; cardiac atrium formation; negative regulation of transcription, DNA-templated; cardioblast anterior-lateral migration; mesodermal cell migration; positive regulation of Notch signaling pathway; positive regulation of transcription by RNA polymerase II; mesoderm formation; somitogenesis; embryonic pattern specification;
	Sources:Amigo / QuickGO
Orthologs
	55897
	17292
	ENSG00000166823
	ENSMUSG00000030544
	Q9BRJ9
	P97309
	NM_018670
	NM_008588
	NP_061140
	NP_032614
	Wikidata
View/Edit Human	View/Edit Mouse

MESP1

Protein-coding gene in the species Homo sapiens

Mesoderm posterior 1 homolog (mouse) is a protein that in humans is encoded by the MESP1 gene.^[5] MESP1 is a transcription factor that regulates cardiovascular progenitor specification.^[6]

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This article uses material from the Wikipedia article MESP1, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] [1]
GRCh38: Ensembl release 89: ENSG00000166823 – Ensembl, May 2017

[refGRCm38Ensembl-2] [2]
GRCm38: Ensembl release 89: ENSMUSG00000030544 – Ensembl, May 2017

[3] [3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] [4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] [5]
"Entrez Gene: Mesoderm posterior 1 homolog (mouse)".

[6] [6]
Bondue A, Lapouge G, Paulissen C, Semeraro C, Iacovino M, Kyba M, Blanpain C (July 2008). "Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification". Cell Stem Cell. 3 (1): 69–84. doi:10.1016/j.stem.2008.06.009. PMID 18593560.

[5]

[6]

[1]

[2]

[3]

[4]

MESP1

MESP1

References

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