MRK-016

MRK-016

MRK-016

Chemical compound

MRK-016 is a selective α5 subunit-containing GABAA negative allosteric modulator,[1] that has nootropic properties. It has been found to produce rapid, ketamine-like antidepressant effects in animal models of depression.[2]

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See also

References

  1. [1]
    Atack JR, Maubach KA, Wafford KA, O'Connor D, Rodrigues AD, Evans DC, et al. (November 2009). "In vitro and in vivo properties of 3-tert-butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2,4-triazol-5-ylmethoxy)-pyrazolo[1,5-d]-[1,2,4]triazine (MRK-016), a GABAA receptor alpha5 subtype-selective inverse agonist". The Journal of Pharmacology and Experimental Therapeutics. 331 (2): 470–84. doi:10.1124/jpet.109.157636. PMID 19704033. S2CID 688293.
  2. [2]
    Fischell J, Van Dyke AM, Kvarta MD, LeGates TA, Thompson SM (October 2015). "Rapid Antidepressant Action and Restoration of Excitatory Synaptic Strength After Chronic Stress by Negative Modulators of Alpha5-Containing GABAA Receptors". Neuropsychopharmacology. 40 (11): 2499–509. doi:10.1038/npp.2015.112. PMC 4569955. PMID 25900119.
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