Malonyl_CoA_reductase_(malonate_semialdehyde-forming)

Malonyl CoA reductase (malonate semialdehyde-forming)

Malonyl CoA reductase (malonate semialdehyde-forming)

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Malonyl CoA reductase (malonate semialdehyde-forming) (EC 1.2.1.75, NADP-dependent malonyl CoA reductase, malonyl CoA reductase (NADP)) is an enzyme with systematic name malonate semialdehyde:NADP+ oxidoreductase (malonate semialdehyde-forming).[1][2][3][4] This enzyme catalyse the following chemical reaction

malonate semialdehyde + CoA + NADP+ malonyl-CoA + NADPH + H+
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Requires Mg2+. Catalyses the reduction of malonyl-CoA to malonate semialdehyde.

References

  1. [1]
    Strauss G, Fuchs G (August 1993). "Enzymes of a novel autotrophic CO2 fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus, the 3-hydroxypropionate cycle". European Journal of Biochemistry. 215 (3): 633–43. doi:10.1111/j.1432-1033.1993.tb18074.x. PMID 8354269.
  2. [2]
    Berg IA, Kockelkorn D, Buckel W, Fuchs G (December 2007). "A 3-hydroxypropionate/4-hydroxybutyrate autotrophic carbon dioxide assimilation pathway in Archaea". Science. 318 (5857): 1782–6. doi:10.1126/science.1149976. PMID 18079405.
  3. [3]
    Alber B, Olinger M, Rieder A, Kockelkorn D, Jobst B, Hügler M, Fuchs G (December 2006). "Malonyl-coenzyme A reductase in the modified 3-hydroxypropionate cycle for autotrophic carbon fixation in archaeal Metallosphaera and Sulfolobus spp" (PDF). Journal of Bacteriology. 188 (24): 8551–9. doi:10.1128/JB.00987-06. PMC 1698253. PMID 17041055.
  4. [4]
    Hügler M, Menendez C, Schägger H, Fuchs G (May 2002). "Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation". Journal of Bacteriology. 184 (9): 2404–10. doi:10.1128/jb.184.9.2404-2410.2002. PMC 134993. PMID 11948153.
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