Mangostin

Mangostin

Mangostin

Chemical compound

Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree (Garcinia mangostana). It is a yellow crystalline solid with a xanthone core structure.

Quick Facts Names, Identifiers ...

Source

The rind of partially ripe mangosteen fruit yields mangostin and also the related compound β-mangostin. Researchers conducted the optimization steps in order to increase the yield of α-mangostin extraction from the pericarp of the mangosteen and was able to achieve 9.2 g/kg DW.[1] The rind of fully ripe fruits also contains the xanthonoids gartanin, 8-disoxygartanin, and normangostin.[citation needed]

Research

Mangostin and a variety of other xanthonoids from mangosteen have been investigated for biological properties including antioxidant, anti-bacterial, anti-inflammatory, and anticancer activities.[2]

In animal studies, mangostin has been found to be a central nervous system depressant which causes sedation, decreased motor activity, and ptosis.[3][better source needed]

A derivative of mangostin, mangostin-3,6-di-O-glucoside, is a central nervous system depressant and causes a rise in blood pressure.[citation needed]

References

  1. [1]
    Khaw, Kooi Yeong; Ong, Yong Sze; Goh, Bey-Hing (2020). "A Rapid Method for the Retrieval of Bioactive Xanthone from Garcinia Mangostana: A Case Study of α-Mangostin". Progress in Drug Discovery & Biomedical Science. 3 (1). doi:10.36877/pddbs.a0000072.
  2. [2]
    Jung H, Su B, Keller W, Mehta R, Kinghorn A (2006). "Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen)". J. Agric. Food Chem. 54 (6): 2077–82. doi:10.1021/jf052649z. PMID 16536578.
  3. [3]
    Shankaranarayan D, Gopalakrishnan C, Kameswaran L (1979). "Pharmacological profile of mangostin and its derivatives". Arch Int Pharmacodyn Ther. 239 (2): 257–269. PMID 314790.
Share this article:

This article uses material from the Wikipedia article Mangostin, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.