Early political career

During the 1950s he began to enter politics, serving on farmers' organizations and Republican committees. In 1962, Andrews ran for governor of North Dakota, losing to incumbent William L. Guy by 2,000 votes out of over 228,500 cast.^[2]

U.S. House

The next year, he became the Republican candidate for a seat in the United States House of Representatives from North Dakota when a special election was required after the death of Congressman Hjalmar Nygaard. Andrews won the election. He was reelected to a full term in 1964 and served in the House until 1981, being reelected every two years. Andrews supported Nelson Rockefeller in the 1964 Republican presidential primaries.^[3] During his time in the House, Andrews voted in favor of the Civil Rights Act of 1964,^[4] the Civil Rights Act of 1968,^[5] and the Voting Rights Act of 1965.^[6] Andrews was one of thirty-one Republicans in the House to vote in favor of the Comprehensive Child Development Act of 1971.^[7]

Senate

In 1980, Andrews did not run for reelection to the House, but instead ran for the United States Senate seat being vacated by long-serving Republican Senator Milton Young, who was retiring. Andrews won the election with 70% of the vote and served in the Senate for one term, from 1981 to 1987.^[8] He was chairman of the select committee on Indian affairs from 1983 to 1987. As Senator and Representative, Andrews was socially moderate to liberal, opposing abortion bans and school prayer, and conservative on economic policies, but was also supportive of subsidies for farmers. Andrews was good friends with Massachusetts Senator Ted Kennedy and Minnesota Representative Bob Bergland.^[3]

Career after Congress

In 1986, Andrews lost reelection to Democratic-NPL Tax Commissioner Kent Conrad by 2,120 votes in what was considered an upset, and subsequently retired from electoral politics. He started a consultancy firm in Washington, D.C., but lived in Mapleton, North Dakota. Grand Forks International Airport in Grand Forks, North Dakota has sometimes been called Mark Andrews International Airport, but usage of the name has declined.

Despite North Dakota's Republican bent at the presidential level, Andrews was the last Republican to represent the state in Congress until 2010, when Rick Berg was elected to the House and John Hoeven to the Senate.