Maslinic_acid

Maslinic acid

Maslinic acid

Chemical compound

Maslinic acid is a compound derived from dry olive-pomace oil (an olive skin wax) which is a byproduct of olive oil extraction. It is a member of the group of triterpenes known as oleananes.

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Pharmacology

In vitro study shows that maslinic acid inhibits serine proteases, key enzymes necessary for the spread of HIV within an individual's body.[1] It also has in vitro antiproliferative effects on colon cancer cells.[2] Maslinic acid increases EAAT2 (GLT-1) glutamate reuptake and may reduce glutamatergic toxicity in rats.[3] Additionally, maslinic acid serves as a glycogen phosphorylase inhibitor in mouse liver,[4][5] as evidenced by increased glycogen accumulation in rainbow trout liver.[6]

Clinical significance

Maslinic acid demonstrates antioxidant capabilities against oxygen and nitrogen reactive species.[7][8] It also exhibits a suppressive impact on proinflammatory cytokines like TNF-α and IL-6 in murine macrophages.[8] These mechanisms could contribute to enhanced protein synthesis, growth rates, and joint support.[9] Maslinic acid has been shown to improve muscle mass in the elderly when combined with resistance exercise.[10]

References

  1. [1]
    University of Granada (11 July 2007). "Compound From Olive-pomace Oil Inhibits HIV Spread". sciencedaily.com. Retrieved 2009-06-16.
  2. [2]
    Juan ME, Planas JM, Ruiz-Gutierrez V, Daniel H, Wenzel U (2008). "Antiproliferative and apoptosis-inducing effects of maslinic and oleanolic acids, two pentacyclic triterpenes from olives, on HT-29 colon cancer cells" (PDF). Br J Nutr. 100 (1): 36–43. doi:10.1017/S0007114508882979. PMID 18298868.
  3. [3]
    Guan T, Qian Y, Guan T, Qian Y, Tang X, Huang M, Huang L, Li Y, Sun M (November 2011). "Maslinic acid, a natural inhibitor of glycogen phosphorylase, reduces cerebral ischemic injury in hyperglycemic rats by GLT-1 up-regulation". J. Neurosci. Res. 89 (11): 1829–39. doi:10.1002/jnr.22671. PMID 21800347.
  4. [4]
    Márquez Martín A, De La Puerta Vázquez R, Fernández-Arche A, Ruiz-Gutiérrez V (2006). "Supressive effect of maslinic acid from pomace olive oil on oxidative stress and cytokine production in stimulated murine macrophages". Free Radical Research. 40 (3): 295–302. doi:10.1080/10715760500467935. ISSN 1071-5762. PMID 16484046.
  5. [5]
    Wen X, Sun H, Liu J, Wu G, Zhang L, Wu X, Ni P (2005-11-15). "Pentacyclic triterpenes. Part 1: The first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases". Bioorganic & Medicinal Chemistry Letters. 15 (22): 4944–4948. doi:10.1016/j.bmcl.2005.08.026. ISSN 0960-894X. PMID 16169219.
  6. [6]
    Vlietinck A, De Bruyne T, Apers S, Pieters L (1998). "Plant-Derived Leading Compounds for Chemotherapy of Human Immunodeficiency Virus (HIV) Infection" (PDF). Planta Medica. 64 (02): 97–109. doi:10.1055/s-2006-957384. ISSN 0032-0943. PMID 9525100.
  7. [7]
    Conlon, Ian; Raff, Martin (1999-01-22). "Size Control in Animal Development". Cell. 96 (2): 235–244. doi:10.1016/S0092-8674(00)80563-2. PMID 9988218.
  8. [8]
    Montilla MP, Agil A, Navarro MC, Jiménez MI, García-Granados A, Parra A, Cabo MM (2003). "Antioxidant Activity of Maslinic Acid, a Triterpene Derivative Obtained from Olea europaea". Planta Medica. 69 (5): 472–474. doi:10.1055/s-2003-39698. ISSN 0032-0943. PMID 12802735.
  9. [9]
    Nierding, Axel. "Acide Maslinique: Propriétés Et Bienfaits" [Maslinic Acid: Properties And Benefits]. Polyvalents (in French). Retrieved 2023-12-25.
  10. [10]
    Nagai N, Yagyu S, Sakane N (2019). "Maslinic acid derived from olive fruit in combination with resistance training improves muscle mass and mobility functions in the elderly". Journal of Clinical Biochemistry and Nutrition. 64 (3): 224–230. doi:10.3164/jcbn.18-104. PMC 6529705. PMID 31138956.
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