Mauro Santambrogio (born 7 October 1984 in Erba) is a former Italian professional road racing cyclist, who last rode for UCI Continental team Amore & Vita–Selle SMP.

Until 2009, Santambrogio rode for Lampre–NGC, and after the 2009 season he changed to BMC Racing Team. In 2010, he was mentioned in the Mantova doping investigation, and was sidelined for a few days by his team; he was again sidelined in 2011 when new evidence showed up.

After leaving BMC at the end of the 2012 season, Santambrogio joined Vini Fantini–Selle Italia. He made an excellent start to the season, including finishing 6th overall in Tour de San Luis, 7th overall in Tirreno–Adriatico and winning the GP Industria & Artigianato di Larciano in pouring rain. He was clear of the group with Patrik Sinkewitz, when Sinkewitz crashed at a right turn with 2 km (1.2 mi) to go. Santambrogio then soloed his way to victory.^[1] Santambrogio then finished 2nd overall in Giro del Trentino. At the Giro d'Italia, Santambrogio won Stage 14 after attacking with race leader Vincenzo Nibali, to rise to fourth overall, and just one second off the final podium place occupied by Rigoberto Urán. However, Santambrogio's form collapsed and he eventually finished 9th overall. Santambrogio's surprising performances had caused rumours amongst the peloton of doping from early in the race.^[2]