Orphaned as a child, Twersky was raised by his uncle Rabbi Nochum, who sent him to be educated in one of the highly acclaimed yeshivot in Lithuania. After his marriage he earned his livelihood as a teacher of young boys, while continuing his intensive studies of Torah.[5]
With the advent of Chassidism, Twersky became a disciple of the Baal Shem Tov, the founder of Hasidism. After the Baal Shem Tov's death, Twersky accepted the Maggid of Mezritch as his mentor. His book Me'or Einayim (Light of the Eyes) was published after his death and contains a collection of his homilies concerning the weekly Torah portions and selections of the Talmud. The book gained widespread acceptance as one of the major works of Hasidic thought.[3]
He was succeeded as the Maggid of Chernobyl by his son Rabbi Mordechai Twerski. The surname would become known as Twersky in the United States. Seven of Mordechai's eight sons became rebbes, including those of Skver, Rachmastrivka, Trisk, and Talner.[6]
Twersky's daughter, Malka, married Rabbi Avraham of Korostyshiv. Their daughter, Chava, wife of Rabbi Sholom Shachne of Prohobisht, was the mother of Rabbi Yisroel Friedman of Ruzhin.