Metazocine
Metazocine
Opioid analgesic
Metazocine is an opioid analgesic related to pentazocine. While metazocine has significant analgesic effects,[2] mediated through a mixed agonist–antagonist action[3] at the mu opioid receptor,[4] its clinical use is limited by dysphoric and hallucinogenic effects which are most likely caused by activity at kappa opioid receptors (where it is a high-efficacy agonist)[5] and/or sigma receptors.[6][7]
Metazocine is in Schedule II of the Controlled Substances Act 1970 of the United States as a Narcotic with ACSCN 9240 with a 19 gram aggregate manufacturing quota as of 2014. The free base conversion ratio for salts includes 0.81 for the hydrochloride and 0.74 for the hydrobromide.[8] It is listed under the Single Convention for the Control of Narcotic Substances 1961 and is controlled in most countries in the same fashion as is morphine.