Methamnetamine

Methamnetamine

Methamnetamine

Chemical compound

Methamnetamine (also known as methylnaphetamine, MNA, MNT and PAL-1046) is a triple monoamine releasing agent and N-methyl analog of the non-neurotoxic experimental drug naphthylaminopropane and the naphthalene analog of methamphetamine.[1][2][3] It has been sold online as a designer drug.[4][5]

Quick Facts Legal status, Identifiers ...

It acts as a releasing agent of serotonin, norepinephrine, and dopamine, with EC50 values of 13 nM, 34 nM, and 10 nM, respectively.[1]

Methamnetamine is illegal in Japan.[6]

See also

References

  1. [1]
    Rothman RB, Partilla JS, Baumann MH, Lightfoot-Siordia C, Blough BE (April 2012). "Studies of the biogenic amine transporters. 14. Identification of low-efficacy "partial" substrates for the biogenic amine transporters". The Journal of Pharmacology and Experimental Therapeutics. 341 (1): 251–262. doi:10.1124/jpet.111.188946. PMC 3364510. PMID 22271821.
  2. [2]
    Youn DH, Kim JM, Hong YK, Park SI, Lee JM, Kim YH, et al. (August 2021). "Assessment of the abuse potential of methamnetamine in rodents: a behavioral pharmacology study". Psychopharmacology. 238 (8): 2155–2165. doi:10.1007/s00213-021-05840-9. PMID 33811503. S2CID 232773019.
  3. [3]
    Hong YK, Kim YH, Lee JM, Yoo HH, Choi SO, Kang MS (July 2021). "Characterization of in vitro phase I metabolites of methamnetamine in human liver microsomes by liquid chromatography-quadrupole time-of-flight mass spectrometry". International Journal of Legal Medicine. 135 (4): 1471–1476. doi:10.1007/s00414-021-02594-z. PMID 33928430. S2CID 233451101.
  4. [4]
    "Methamnetamine". WEDINOS.
  5. [5]
    "Methamnetamine". New Synthetic Drugs Database.
  6. [6]
    "指定薬物名称・構造式一覧（平成27年9月16日現在）" [List of designated drug names and structural formulas (as of September 16, 2015)] (PDF). 厚生労働省 [Ministry of Health, Labour and Welfare] (in Japanese). 16 September 2015. Retrieved 8 October 2015.
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