This is a list of foreign ministers of Paraguay from 1846 to the present day.

• 1846–1855: José Falcón
• 1855–1862: Nicolás Vázquez
• 1862: Domingo Francisco Sánchez
• 1862–1868: José Berges
• 1868: Gumersindo Benítez (acting)
• 1868–1869: Luis Caminos
• 1869–1870: Serapio Machaín (acting)
• 1870: Bernardo Recalde (acting)
• 1870–1871: Miguel Palacios
• 1871: Carlos Loizaga
• 1871: José Segundo Decoud
• 1871–1872: José Falcón
• 1872–1873: Gregorio Benítez Inchausti
• 1873–1874: José del Rosario Miranda (acting)
• 1874: Cándido Bareiro
• 1874: Higinio Uriarte
• 1874–1877: Facundo Machaín
• 1877: Benjamín Aceval
• 1877–1878: Juan Antonio Jara
• 1878–1880: Benjamín Aceval
• 1880–1886: José Segundo Decoud
• 1886–1887: Benjamín Aceval
• 1887: Agustín Cañete (acting)^[1]
• 1887–1888: José Segundo Decoud
• 1888–1890: Juan Crisóstomo Centurión
• 1890–1894: Venancio Víctor López
• 1894–1895: Héctor Velázquez
• 1895–1900: José Segundo Decoud
• 1900–1901: Fabio Queirolo
• 1901–1902: Juan Cancio Flecha
• 1902: Manuel Domínguez
• 1902–1903: Pedro Pablo Peña
• 1903: Cayetano Carreras
• 1903–1904: Antolín Irala
• 1904–1905: Gualberto Cardús Huerta
• 1905: Cecilio Báez
• 1905–1906: Cayetano Carreras (acting)
• 1906: Adolfo Rufo Soler
• 1906–1908: Cecilio Báez
• 1908: Eusebio Ayala
• 1908–1910: Manuel Gondra
• 1910–1911: Héctor Velázquez
• 1911: Cecilio Báez
• 1911: Teodosio González
• 1911: Carlos Luis Isasi
• 1911–1912: Antolín Irala
• 1912: Fulgencio Ricardo Moreno
• 1912: Félix Paiva
• 1912: Eusebio Ayala
• 1912–1913: Félix Paiva
• 1913–1918: Manuel Gondra
• 1918–1919: Eusebio Ayala
• 1919–1920: Ramón Lara Castro
• 1920–1921: Manuel Peña Rojas
• 1921–1923: Alejandro Arce
• 1923–1924: Rogelio Ibarra Muñoz
• 1924–1925: Manuel Peña Rojas
• 1925–1928: Enrique Bordenave
• 1928–1931: Gerónimo Zubizarreta
• 1931–1932: Raúl Casal Ribeiro
• 1932: Higinio Arbo
• 1932–1934: Justo Pastor Benítez
• 1935–1936: Luis Alberto Riart
• 1936–1937: Juan Stefanich
• 1937–1938: Cecilio Báez
• 1938–1939: Elías Ayala
• 1939–1940: Justo Pastor Prieto Rojas
• 1940: Justo Pastor Benítez
• 1940: Tomás Andrés Salomoni
• 1940–1944: Luis Andrés Argaña
• 1944–1946: Horacio Chiriani Cotor
• 1946: Antonio Alberto Taboada
• 1946–1947: Miguel Ángel Soler
• 1947: Federico Chaves
• 1947–1948: César Augusto Vasconsellos
• 1948: Domingo Montanaro
• 1948–1949: Juan Emiliano O'Leary (acting)
• 1949: Federico Chaves
• 1949–1952: Bernardo Ocampos
• 1952–1953: Ángel Florentín Peña (acting to 1953)
• 1953–1954: José Antonio Moreno González
• 1954–1956: Hipólito Sánchez Quell
• 1956–1976: Raúl Sapena Pastor
• 1975–1983: Alberto Nogués (acting for Sapena to 1976)
• 1983–1988: Carlos Augusto Saldívar
• 1988–1989: Rodney Elpidio Acevedo
• 1989–1990: Luis María Argaña
• 1990–1993: Alexis Frutos Vaesken
• 1993: Diógenes Martínez
• 1993–1996: Luis María Ramírez Boettner
• 1996–1998: Rubén Melgarejo Lanzoni
• 1998–1999: Dido Florentín Bogado
• 1999: Miguel Abdón Saguier
• 1999–2000: José Félix Fernández Estigarribia
• 2000–2001: Juan Esteban Aguirre Martínez
• 2001–2003: José Antonio Moreno Ruffinelli
• 2003–2006: Leila Rachid de Cowles
• 2006–2008: Rubén Ramírez Lezcano
• 2008–2009: Alejandro Hamed
• 2009–2011: Héctor Lacognata
• 2011–2012: Jorge Lara Castro
• 2012–2013: José Félix Fernández Estigarribia
• 2013–2018: Eladio Loizaga
• 2018–2019: Luis Castiglioni
• 2019–2020: Antonio Rivas Palacios
• 2020–2021: Federico González Franco
• 2021–2022: Euclides Acevedo
• 2022–2023: Julio Arriola
• 2023–present: Rubén Ramírez Lezcano