Route 81 is a highway in northeastern Missouri. Its northern terminus is at the Iowa state line where it continues as Iowa Highway 81. Its southern terminus is at Route 16 west of Canton.

Quick Facts Route 81, Route information ...

Route 81
Route 81 highlighted in red
Route information
Maintained by MoDOT
Length	40.954 mi[1] (65.909 km)
Major junctions
South end	Route 16 west of Canton
Major intersections	US 136 south of Kahoka
North end	Iowa 81 near Farmington, IA
Location
Country	United States
State	Missouri
Highway system
Missouri State Highway System Interstate US State Supplemental
← Route 80 → Route 82

Close

Route 81 starts at the Iowa state line from Iowa Route 81. It continues south into the town of Kahoka and then intersects with US Route 136. As it continues south, there are several sharp turns. It ends outside of the town Canton, near an interchange with US 61 and intersects with Route 16. The route starts in Clark county and ends in Lewis county.