The Musone (Latin: Misco)^[1] is a river in the Marche region of Italy. The source of the river is east of Matelica and south of Monte San Vicino in the province of Macerata.^[2] The river flows northeast near Apiro, Cingoli and Staffolo before crossing into the province of Ancona near Filottrano. The river then flows southeast and is joined by a tributary south of Osimo before curving northeast near Loreto. Finally, the river empties into the Adriatic Sea north of Porto Recanati and south of Numana.