N-succinylornithine_carbamoyltransferase

N-succinylornithine carbamoyltransferase

N-succinylornithine carbamoyltransferase

Add article description

N-succinylornithine carbamoyltransferase (EC 2.1.3.11, succinylornithine transcarbamylase, N-succinyl-L-ornithine transcarbamylase, SOTCase) is an enzyme with systematic name carbamoyl phosphate:N2-succinyl-L-ornithine carbamoyltransferase.[1][2] This enzyme catalyses the following chemical reaction

carbamoyl phosphate + N2-succinyl-L-ornithine phosphate + N-succinyl-L-citrulline
Quick Facts Identifiers, EC no. ...

This enzyme is specific for N-succinyl-L-ornithine.

References

  1. [1]
    Shi D, Morizono H, Cabrera-Luque J, Yu X, Roth L, Malamy MH, Allewell NM, Tuchman M (July 2006). "Structure and catalytic mechanism of a novel N-succinyl-L-ornithine transcarbamylase in arginine biosynthesis of Bacteroides fragilis". The Journal of Biological Chemistry. 281 (29): 20623–31. doi:10.1074/jbc.M601229200. PMID 16704984.
  2. [2]
    Shi D, Yu X, Cabrera-Luque J, Chen TY, Roth L, Morizono H, Allewell NM, Tuchman M (August 2007). "A single mutation in the active site swaps the substrate specificity of N-acetyl-L-ornithine transcarbamylase and N-succinyl-L-ornithine transcarbamylase". Protein Science. 16 (8): 1689–99. doi:10.1110/ps.072919907. PMC 2203365. PMID 17600144.
Share this article:

This article uses material from the Wikipedia article N-succinylornithine_carbamoyltransferase, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.