N6AMT1

N6AMT1

N6AMT1

Protein-coding gene in the species Homo sapiens

N-6 adenine-specific DNA methyltransferase 1 is a protein that in humans is encoded by the N6AMT1 gene. [5]

Quick Facts Identifiers, Aliases ...

Function

The N6AMT1 gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jul 2014]. N6AMT1 functions as a protein glutamine methyltransferase and is essential for mouse development (Liu et al., Mol. Cell. Biol. 2010).

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000156239 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000044442 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: N-6 adenine-specific DNA methyltransferase 1". Retrieved 2018-08-24.

Further reading


Peng Liu,Song Nie, Bing Li,Zhong-Qiang Yang, Zhi-Mei Xu, Jian Fei, Chyuansheng Lin, Rong Zeng, and Guo-Liang Xu. Deficiency in a Glutamine-Specific Methyltransferase for Release Factor Causes Mouse Embryonic Lethality. MOLECULAR AND CELLULAR BIOLOGY, Sept. 2010, p. 4245–4253 Vol. 30, No. 17 0270-7306/10/


This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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