NKX2-2

NKX2-2

NKX2-2

Protein-coding gene in the species Homo sapiens

Homeobox protein Nkx-2.2 is a protein that in humans is encoded by the NKX2-2 gene.[5][6][7]

Quick Facts Identifiers, Aliases ...

Homeobox protein Nkx-2.2 contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor.[7]

The expression of Nkx2-2 is regulated by an antisense RNA called Nkx2-2as.[8]

In the developing spinal cord, Nkx-2.2 regulates IRX3 thereby contributing to the proper differentiation of the ventral horn neurons.[9]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000125820 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000027434 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Furuta H, Horikawa Y, Iwasaki N, Hara M, Sussel L, Le Beau MM, Davis EM, Ogata M, Iwamoto Y, German MS, Bell GI (Aug 1998). "Beta-cell transcription factors and diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-onset diabetes of the young in Japanese". Diabetes. 47 (8): 1356–1358. doi:10.2337/diabetes.47.8.1356. PMID 9703340.
  6. [6]
    Price M, Lazzaro D, Pohl T, Mattei MG, Rüther U, Olivo JC, Duboule D, Di Lauro R (Feb 1992). "Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain". Neuron. 8 (2): 241–255. doi:10.1016/0896-6273(92)90291-K. PMID 1346742. S2CID 22766848.
  7. [7]
    "Entrez Gene: NKX2-2 NK2 transcription factor related, locus 2 (Drosophila)".
  8. [8]
    Tochitani S, Hayashizaki Y (Aug 2008). "Nkx2.2 antisense RNA overexpression enhanced oligodendrocytic differentiation". Biochemical and Biophysical Research Communications. 372 (4): 691–696. doi:10.1016/j.bbrc.2008.05.127. PMID 18538132.
  9. [9]
    Lovrics A, Gao Y, Juhász B, Bock I, Byrne HM, Dinnyés A, Kovács KA (November 2014). "Boolean modelling reveals new regulatory connections between transcription factors orchestrating the development of the ventral spinal cord". PLOS ONE. 9 (11): e111430. Bibcode:2014PLoSO...9k1430L. doi:10.1371/journal.pone.0111430. PMC 4232242. PMID 25398016.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Stub icon

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article NKX2-2, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.