NOL6

NOL6

NOL6

Protein-coding gene in the species Homo sapiens

Nucleolar protein 6 is a protein that in humans is encoded by the NOL6 gene.[5][6][7]

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The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified.[7]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000165271 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000028430 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Utama B, Kennedy D, Ru K, Mattick JS (Mar 2002). "Isolation and characterization of a new nucleolar protein, Nrap, that is conserved from yeast to humans". Genes Cells. 7 (2): 115–32. doi:10.1046/j.1356-9597.2001.00507.x. PMID 11895476. S2CID 21385000.
  6. [6]
    Bernstein KA, Gallagher JE, Mitchell BM, Granneman S, Baserga SJ (Dec 2004). "The small-subunit processome is a ribosome assembly intermediate". Eukaryot Cell. 3 (6): 1619–26. doi:10.1128/EC.3.6.1619-1626.2004. PMC 539036. PMID 15590835.
  7. [7]
    "Entrez Gene: NOL6 nucleolar protein family 6 (RNA-associated)".

Further reading


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