Naphthylvinylpyridine

Naphthylvinylpyridine

Naphthylvinylpyridine

Chemical compound

Naphthylvinylpyridine (NVP) is a naphthalene derivative that possesses anticholinergic activity similar to that of atropine. However, NVP's method of acetylcholine (ACh) antagonism involves inhibiting the enzyme choline acetyltransferase.[1]

Quick Facts Names, Identifiers ...

Several NVP derivatives have been synthesized and evaluated for their ability to inhibit choline acetyltransferase and protect against nerve toxins.[2][3]

References

  1. [1]
    Haubrich, DR; Goldberg, ME (1975). "Homovanillic acid concentration in the rat brain: Effect of a choline acetyltransferase inhibitor and comparison with cholinergic and dopaminergic agents". Neuropharmacology. 14 (3). Squibb Institute for Medical Research: 211–214. doi:10.1016/0028-3908(75)90007-6. PMID 1134625. S2CID 28216329.
  2. [2]
    Cozzari, Costantino; Hartman, BK (1983). "Synthesis of a naphthylvinylpyridine derivative and its use for affinity chromatography of choline acetyltransferase". Analytical Biochemistry. 133 (1). Department of Psychiatry and Neurobiology, Washington University School of Medicine: 120–125. doi:10.1016/0003-2697(83)90231-2. PMID 6638474.
  3. [3]
    Gray, AP; Henderson, TR (1988). "Approaches to protection against nerve agent poisoning". J Med Chem. 31 (4). Dynamac Corporation: 807–814. doi:10.1021/jm00399a022. PMID 3351860.


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