NatA_acetyltransferase
NatA acetyltransferase(Nα acetyltransferase), is an enzyme that serves to catalyze the addition of acetyl groups to various proteins emerging from the ribosome. Upon translation, the NatA binds to the ribosome and then "stretches" to the front end of the forming, or nascent, polypeptide, where it adds this acetyl group. This acetyl group is added to the front end, or N-terminus of the new protein.
Forty percent of all proteins in the yeast proteome are thought to be N-terminally acetylated, with a corresponding figure of 90% in mammalian proteins.[1]
To be specific, NatA is the main N{alpha}-terminal acetyltransferase in the yeast cytosol, responsible for the acetylation of proteins at locations in which L-serine, L-alanine, L-threonine, or glycine are present.[2][3]
NatA Acetyltransferase is not a single protein but a complex of three subunits.