Film

In her film debut Species (1995), Henstridge played Sil, a genetically engineered alien/human hybrid created from a message received by SETI, who breaks free from the captivity of a laboratory. Pursued by a team of experts who band together to stop her, she embarks on a killing spree while also discovering her powerful instinct to mate, which would result in her offspring being a threat to mankind.^[5] Species was an instant hit, making US$113 million at the box office.^[6] Notable for its sexual content, the film won Henstridge the MTV Movie Award for Best Kiss for a scene in which her character, while kissing an abusive date, impales his head with her tongue. In 1998, she played Eve, a more ambiguous genetic duplicate of Sil, in Species II, which was a failure at the box office. Between Species films, Henstridge starred in two low-budget action films in 1996, Adrenalin: Fear the Rush with Christopher Lambert and Maximum Risk opposite Jean-Claude Van Damme.^[5]

A few smaller independent movies followed, including Bela Donna and Dog Park, with varied box-office returns. Henstridge starred in the film The Whole Nine Yards (2000) and its sequel The Whole Ten Yards (2004). Despite having some reservations about the science-fiction genre, she signed up for John Carpenter's Ghosts of Mars (2001) in the lead role of Lieutenant Melanie Ballard. The film was not well received, with a 20% rating on Rotten Tomatoes.^[7] In 2004, she briefly appeared as Eve in Species III.

In 2007, Henstridge was a festival judge at the first annual Noor Iranian Film Festival.

Television

Henstridge has played a number of roles on television, for example in Caracara and The Outer Limits. From 2005 to 2006, she had a recurring role as the speaker's chief of staff on the ABC drama Commander in Chief, which starred Geena Davis as a fictional female U.S. President. She also hosted Mostly True Stories: Urban Legends Revealed on TLC, a show about urban legends. She guest-starred as a substitute teacher in the first-season South Park episode "Tom's Rhinoplasty", and was credited as "the chick from Species".

Henstridge was working on the television series She Spies, prior to its cancellation. She has also completed a television movie for the Lifetime channel titled Widow on the Hill. In 2006, she filmed the CTV original miniseries Would Be Kings in Hamilton, Ontario,^[8] for which she won a Gemini Award.^[9] She also starred in the expansion set to the video game Command and Conquer 3: Tiberium Wars, entitled Kane's Wrath.^[10]

In 2008, Henstridge played a role on the ABC comedy-drama series Eli Stone. She has also been involved with two other productions, joining the cast of Dave Rodriguez's Anytown, an indie drama that examines a racist high-school attack and its aftermath. She has also been involved with the production of Should've Been Romeo from American Independent Pictures.

In 2009, Henstridge did a guest spot on The Tonight Show with Conan O'Brien. During this, she demonstrated a Newfoundland custom called "screeching in", which involved getting O'Brien to drink Newfoundland Screech rum and kiss a large fish.^[11]

In 2011, she appeared on the season-9 finale and season-10 premiere of CSI: Miami as Renee Locklear. She then starred in the CW television series The Secret Circle as Dawn Chamberlain.

From 2019 to 2022, she starred in the CBC Television/BET+ drama series Diggstown.^[2]

Film

Television