Natriuretic_peptide_receptor_A

NPR1

NPR1

Protein-coding gene in the species Homo sapiens

For another use, see Arabidopsis thaliana.

Natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A), also known as NPR1, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR1 gene.

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Function

NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP and BNP, respectively).[5]

It is localized in the kidney[6] where it results in natriuresis upon binding to natriuretic peptides. However, it is found in even greater quantity in the lungs and adipocytes.[6]

See also

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000169418 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000027931 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: NPR1 natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)".
  6. [6]
    BioGPS > NPR1 Retrieved Nov 2010 Archived November 27, 2010, at the Wayback Machine

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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