Modern era

The Spiders were replaced in Cleveland by a minor league team called the Lake Shores in the American League for the 1900 season. The AL declared itself a major league for the 1901 season with the Cleveland franchise, then called the Blues, as a charter member. The team was later called the Bronchos and Naps before being named the Indians in 1915 and Guardians in 2022. Because the two teams are part of different leagues, however, the only chance for them to meet prior to the introduction of Interleague Play in 1997 was in exhibition games or in the World Series. The Indians and Reds came close to meeting on three occasions, first when Cincinnati won the tainted 1919 World Series with the Indians 3+1⁄2 games back in the AL. The following season, the Indians won the World Series with the Reds third in the NL. In 1940, the Reds again won the World Series with the Indians finishing one game back in the American League.

Through 2021, the teams have only made the playoffs in the same season three times. The first time was in 1995 when both teams won their respective division and advanced to their respective League Championship Series. Both teams, however, fell to the eventual champion Atlanta Braves as the Reds were lost the National League Championship Series and the Indians lost the World Series. The Reds and Indians both made the playoffs again in 2013 as wild-card teams, and both were eliminated in their respective Wild Card Games. Likewise, both teams were wild card entries in 2020 but each lost in the first round.

Ohio Championship Series

In July 1910, the Cincinnati manager challenged the Cleveland Naps to a seven-game "Championship of Ohio" series, which was held after the conclusion of the regular season. The Reds won the opener in Cincinnati, 14–7, and ultimately won the series 4–3, with the home team winning all seven games. After the 1911 season, the series was held again, with the Reds winning 4–2. The opener of the 1911 series, however, only drew 580 fans in Cincinnati, and while the remaining games, all played at League Park in Cleveland, drew better, the series was discontinued.^[10]

First Ohio Cup

Details of the original Ohio Cup were unveiled at a press conference on August 25, 1988. At that time, the two teams occasionally played each other in spring training and had yet to make the post-season in the same season. The managers of both teams did not treat the cup game as anything more than an exhibition, but many fans in Columbus treated it like a referendum on major league sports in the city as, at that time, Columbus did not have any major sports franchises.^[11]

Sitting between Cleveland and Cincinnati, the city was always divided when it came to allegiance to the state's big league teams. "Half the fans (in Columbus) love the Reds and hate the Indians and the other half love the Indians and hate the Reds. It's a great matchup", said the game's promoter, Keith Sprunk.^[11] Indians manager Doc Edwards agreed. "I'll love to play it, it's great. San Francisco and Oakland do the same thing. I'd like to see (the Ohio Cup) become an annual thing, either during the spring or in the summer."^[11] Crowds averaged 15,910 fans for the first five Ohio Cups at the 15,000-seat Cooper Stadium. Those crowds ranked 3rd, 4th, 7th, 9th and 12th among all-time largest baseball crowds at the stadium. Only about 2000 made it out in 1995 with temperatures near freezing and replacement players taking the field.

The first Ohio Cup match-up was marred by 40 °F (4 °C) temperatures made colder by constant rain and brisk wind. Cleveland started only four regulars while Cincinnati opted to play seven of their nine starters. It remained scoreless until the top of the eighth inning when a throwing error by Reds outfielder Herm Winningham allowed Luis Aguayo to score the only run. Minor league pitcher Greg McMichael received the win while Reds' reliever Mike Griffin was credited with the loss.

In the 1990 contest, catchers Sandy Alomar Jr. and Joel Skinner combined for six RBI as the Indians won their second straight Ohio Cup before a standing-room only crowd. In an action-packed game, the Indians banged out 13 hits, including six in the fourth inning which resulted in seven-runs. Cory Snyder hit a monster blast off Danny Jackson that traveled well past the 400-foot sign in straightaway center field. Alomar homered twice, the first a three-run shot to left-center, the second a solo effort. Skinner hit a two-run shot after being brought in to replace Alomar.

Indians outfielder Albert Belle hit his eleventh home run of the exhibition season as the Indians beat the defending World Series Champion Reds 4–3 in 1991. Jerry Browne hit a sacrifice fly in the seventh inning to lift the Indians to victory. The Reds finally ended their rivals' supremacy in 1992. Cincinnati took the lead in the first. Lead off hitter Bip Roberts doubled and later scored. They added another run in the fourth. Reds' third baseman Chris Sabo counted an RBI double among his two hits while Albert Belle hit two of his team's four hits.

Mike Bielecki stopped Cincinnati on one run and four hits in six innings and Albert Belle had a three-run single as the Tribe won their fourth Ohio Cup in five years in the 1993 contest. Highlights included a home run by Indians' first baseman Paul Sorrento. The only Reds run was scored by Barry Larkin.

In 1994, Manny Ramírez and Paul Sorrento homered in a five-run second inning to help give the Indians an 8–4 win. Mark Clark pitched seven innings, allowing five hits and three runs, walking one and striking out five to gain the win. Albert Belle and Eddie Murray led off the second inning with singles and Sorrento followed with his homer. After Jim Thome singled, Ramírez homered. All five runs came off Tom Browning.

With the 1994–95 Major League Baseball strike only coming to an end on April 2, replacement players traveled to Columbus to take part in the 1995 edition. Teamsters picketed outside the stadium as snow fell. With temperatures near freezing and replacements Tim Delgado and Rich Sauveur taking the mound, only a couple thousand fans made it out. The Reds won the game 6–1.

A line drive single by Julio Franco in the fifth inning broke a 3–3 tie as Cleveland defeated Cincinnati 5–3 to win the final Ohio Cup in 1996. Manny Ramírez had given Cleveland a 3–1 lead with a three-run homer to left field in the second off the Reds' Mark Portugal. Hal Morris drove in two runs for the Reds with a first-inning single and a double in the third, with Bret Boone scoring both times. A single by Vince Coleman in the fifth drove in Jeff Branson and tied the score at 3–3. The victory gave the Indians a 6–2 lead in the Ohio Cup series and was viewed by 16,697 people, the largest crowd in the game's history and the second largest at Cooper Stadium. Indians starter Joe Roa was the winning pitcher.

Ohio Cup revived

The Ohio Cup was reintroduced in 2008 with a new trophy. The trophy is 3 feet high, with a 12-inch stainless cup in the middle. It is awarded to the team that wins the season series in a given year. When the teams split the season series, the team that currently holds the trophy retains it. Through the 2022 season, the Indians/Guardians have won the trophy six times, the Reds four times, with six ties.^[12]

In the revived trophy's inaugural season, the Reds swept the first three-game series at home, which took place May 16–18 2008, after three strong performances by Edinson Vólquez, Aaron Harang, and Johnny Cueto. As the series moved back to Cleveland on June 27–29, with the Indians' CC Sabathia throwing a 6–0 shutout against the Reds in the first game. In the second, the Reds battled back with a strong effort by Cueto to win game two 5–0. The Cincinnati Reds clinched the cup with this win. In the final game in Cleveland, the Reds overcame a late surge by the Tribe to win 9–5, and the series itself 5 games to 1. Ballots were passed out in the middle of the final game for the MVP, awarded to Reds outfielder Adam Dunn, who had a combined five home runs and 10 RBI in the series.

In 2009, the Reds retained the trophy, winning four of the six contests. The Reds took two of the three games in Cincinnati in May, and went on to win two of the three games in Cleveland in June. In 2010, the Reds won the Ohio Cup again, winning 2 of 3 games in Cincinnati, and again winning 2 of 3 games in Cleveland. The Indians won the trophy in 2011 by sweeping the first series in Cleveland, and winning 2 of 3 in the Cincinnati series. The Indians retained the trophy In 2012 and 2013 as the two teams split the Ohio Cup series, with each team sweeping their respective home series.

Beginning in 2013, this rivalry, along with all other interleague rivalries, played four games per year in two back-to-back two game series, instead of six games as they played through 2012. From 2013 to 2017 the two teams would play in one city on a Monday and Tuesday and the other city that Wednesday and Thursday. Since 2019, the teams now play the four games in separate two-game series due to changes in the MLB schedule. The teams played six games in separate three game series in 2015 and 2018, and are expected to do so in years in which the AL Central and NL Central are matched up against each other.

The Indians dominated the series in 2015 and 2016, winning nine of the ten games during those years including the only season-sweep by either team in 2016.

On May 7, 2021, Reds P Wade Miley threw the first and, to date, only no-hitter in the series, leading the Reds to a 3–0 win at Progressive Field.

Results summary

Note: All game scores are listed with the visiting score first