Olah_reagent

Olah reagent

Olah reagent

Add article description

The Olah reagent is a nucleophilic fluorinating agent. It consists of a mixture of 70% hydrogen fluoride and 30% pyridine; alcohols react with this reagent to give alkyl fluorides:

It acts as a stabilized, less volatile form of hydrogen fluoride. It is used in the fluorination of steroids and in deprotection of peptides.[1][2][3] Instead of hydrogen fluoride, several other fluorinating agents can be used, such as diethylaminosulfur trifluoride (DAST).

See also

References

  1. [1]
    C. G. Bergstrom et al., J. Org. Chem. 28, 2633 (1963)
  2. [2]
    G. A. Olah et al., Synthesis 1973, 779; idem et al., J. Org. Chem. 44, 3872 (1979).
  3. [3]
    Review of use in organic synthesis: G. A. Olah et al., J. Fluorine Chem. 33, 377–396 (1986).
Share this article:

This article uses material from the Wikipedia article Olah_reagent, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.