The Ole Miss Rebels football statistical leaders are individual statistical leaders of the Ole Miss Rebels football program in various categories,^[1] including passing, rushing, receiving, total offense, defensive stats, and kicking. Within those areas, the lists identify single-game, single-season, and career leaders. The Rebels represent the University of Mississippi in the NCAA's Southeastern Conference.

Although Ole Miss began competing in intercollegiate football in 1893,^[1] the school's official record book considers the "modern era" to have begun in 1933. Records from before this year are often incomplete and inconsistent, and they are generally not included in these lists.

These lists are dominated by more recent players for several reasons:

• Since 1933, seasons have increased from 10 games to 11 and then 12 games in length.
• The NCAA didn't allow freshmen to play varsity football until 1972 (with the exception of the World War II years), allowing players to have four-year careers.
• Bowl games only began counting toward single-season and career statistics in 2002.^[2] The Rebels have played in eight bowl games since then, allowing players to accumulate stats for an additional game in those seasons.
• The Rebels have accumulated over 5,000 offensive in each of the last eight seasons.

These lists are updated through the 2021 season.

Total offense is the sum of passing and rushing statistics. It does not include receiving or returns.^[40]