2016

Subsequently, Team Dimension Data announced that Fraile would join them for the 2016 season.^[9] He was named in the start list for the 2016 Giro d'Italia,^[10] but abandoned the race on Stage 5.^[11] However, before abandoning, Fraile managed to wear the Mountains Jersey on stage 3 after collecting enough points on stage 2. Fraile then won the Mountains classification at the Vuelta a Burgos. He then rode the Vuelta a España where he won the Mountains classification once again.^[12]

2017

One week before riding the Giro d'Italia, Fraile finished 2nd on the final stage of the Tour de Yorkshire, and therefore 2nd in the general classification. On stage 11 of the Giro d'Italia, Fraile made the breakaway and ended up winning the stage in a sprint between his breakaway companions.^[13] He also managed to pick up points for the Mountains classification which made him wear the Mountains Jersey for 2 days, after eventually losing it later in the race.

2018

At the Paris-Nice, Fraile finished 2nd on the final stage behind David de la Cruz in the sprint.^[14] However a month later he took revenge by winning stage 5 at the Tour of the Basque Country.^[15] At the end of April, Fraile won the bunch sprint on stage 1 at the Tour de Romandie.^[16] Fraile finished 3rd at Spanish National Road Race Championships.^[17]

In July 2018, he was named in the start list for the 2018 Tour de France.^[18] He went on to win stage 14 of the race.^[19] Fraile was placed 57th on the final general classification of the Tour de France 2018.^[20]

On 4 August 2018, Fraile competed in Clásica de San Sebastián and was placed 24th; 52 seconds behind winner Julian Alaphilippe.^[21]