Oxypertine

Oxypertine

Oxypertine

Antipsychotic medication

Oxypertine (Equipertine, Forit, Integrin, Lanturil, Lotawin, Opertil) is an antipsychotic used in the treatment of schizophrenia.[2] It was also evaluated for the treatment of anxiety at a dosage of 20 mg per day.[3] Chemically, it is an indole and phenylpiperazine derivative.[4] Like reserpine and tetrabenazine, oxypertine depletes catecholamines, though not serotonin, possibly underlying its neuroleptic efficacy.[5] Its structure is similar to solypertine and milipertine.

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See also

References

  1. [1]
    Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. [2]
    Hall C, Rhodes PH (1996). Dictionary of organic compounds. London: Chapman & Hall. ISBN 0-412-54090-8.
  3. [3]
    Somohano MD, Broissin MC, Sobrino ZA (1976). "[Clinical evaluation of oxypertine in anxiety conditions]". Neurologia, Neurocirugia, Psiquiatria (in Spanish). 17 (3): 171–180. PMID 12484.
  4. [4]
    Breulet M, Labar P, Delree C, Collard J, Bobon J (February 1968). "[Oxypertine, peperazine derivative of tryptophan with neuroleptic and dynamogenic properties]". Acta Neurologica et Psychiatrica Belgica (in French). 68 (2): 116–127. PMID 4972600.
  5. [5]
    Bak IJ, Hassler R, Kim JS (1969). "Differential monoamine depletion by oxypertine in nerve terminals. Granulated synaptic vesicles in relation to depletion of norepinephrine, dopamine and serotonin". Zeitschrift für Zellforschung und Mikroskopische Anatomie. 101 (3): 448–462. doi:10.1007/BF00335580. PMID 5362847. S2CID 32583722.
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