PCSK7

PCSK7

PCSK7

Protein-coding gene in the species Homo sapiens

Proprotein convertase subtilisin/kexin type 7 is an enzyme that in humans is encoded by the PCSK7 gene.[5][6][7]

Quick Facts Identifiers, Aliases ...

The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease. It is structurally related to its family members, PACE and PACE4. This protein is concentrated in the trans-Golgi network, associated with the membranes, and is not secreted. It can process proalbumin and is thought to be responsible for the activation of HIV envelope glycoproteins gp160 and gp140.

This gene has been implicated in the transcriptional regulation of housekeeping genes. Multiple alternatively spliced transcripts are described for this gene but their full length nature is not yet known. Downstream of this gene's map location at 11q23-q24, nucleotides that match part of this gene's 3' end are duplicated and inverted. A translocation breakpoint associated with lymphoma occurs between this gene and its inverted counterpart.[7]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000160613 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000035382 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Bruzzaniti A, Goodge K, Jay P, Taviaux SA, Lam MH, Berta P, Martin TJ, Moseley JM, Gillespie MT (Jun 1996). "C8, a new member of the convertase family". Biochem J. 314 ( Pt 3) (Pt 3): 727–31. doi:10.1042/bj3140727. PMC 1217117. PMID 8615762.
  6. [6]
    Goodge KA, Thomas RJ, Martin TJ, Gillespie MT (Jan 1999). "Gene organization and alternative splicing of human prohormone convertase PC8". Biochem J. 336 ( Pt 2) (Pt 2): 353–9. doi:10.1042/bj3360353. PMC 1219878. PMID 9820811.
  7. [7]
    "Entrez Gene: PCSK7 proprotein convertase subtilisin/kexin type 7".

[[]]

Further reading

Stub icon

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article PCSK7, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.