POLDIP2

POLDIP2

POLDIP2

Protein-coding gene in the species Homo sapiens

Polymerase delta-interacting protein 2 also known as Polymerase delta-interacting protein of 38 kDa (PDIP38) is encoded by the POLDIP2 gene in humans.[5][6]

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This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. The encoded protein also interacts with proliferating cell nuclear antigen. Some transcripts of this gene overlap in a tail-to-tail orientation with the gene for tumor necrosis factor, alpha-induced protein 1 (TNFAIP1).[6] POLDIP2 / PDIP38 is a moonlighting protein that has been identified in both the nucleus [7] and the mitochondrion [8][9]

Interactions

In the nucleus, POLDIP2 has been shown to interact with PCNA,[5] while in the mitochondrion POLDIP2 has been shown to interact with proteins constituting the mitochondrial DNA nucleoid [10] and the AAA+ protease CLPXP [9][11] where it modulates both the specificity and stability of this proteolytic machine.

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000004142 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000001100 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (March 2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". The Journal of Biological Chemistry. 278 (12): 10041–7. doi:10.1074/jbc.M208694200. PMID 12522211.
  6. [6]
    "Entrez Gene: POLDIP2 polymerase (DNA-directed), delta interacting protein 2".
  7. [7]
    Wong A, Zhang S, Mordue D, Wu JM, Zhang Z, Darzynkiewicz Z, et al. (October 2013). "PDIP38 is translocated to the spliceosomes/nuclear speckles in response to UV-induced DNA damage and is required for UV-induced alternative splicing of MDM2". Cell Cycle. 12 (19): 3184–93. doi:10.4161/cc.26221. PMC 3865014. PMID 23989611.
  8. [8]
    Xie B, Li H, Wang Q, Xie S, Rahmeh A, Dai W, Lee MY (June 2005). "Further characterization of human DNA polymerase delta interacting protein 38". The Journal of Biological Chemistry. 280 (23): 22375–84. doi:10.1074/jbc.M414597200. PMID 15811854.
  9. [9]
    Strack PR, Brodie EJ, Zhan H, Schuenemann VJ, Valente LJ, Saiyed T, et al. (November 2020). "Polymerase delta-interacting protein 38 (PDIP38) modulates the stability and activity of the mitochondrial AAA+ protease CLPXP". Communications Biology. 3 (1): 646. doi:10.1038/s42003-020-01358-6. PMC 7647994. PMID 33159171.
  10. [10]
    Cheng X, Kanki T, Fukuoh A, Ohgaki K, Takeya R, Aoki Y, et al. (December 2005). "PDIP38 associates with proteins constituting the mitochondrial DNA nucleoid". Journal of Biochemistry. 138 (6): 673–8. doi:10.1093/jb/mvi169. PMID 16428295.
  11. [11]
    Paredes F, Sheldon K, Lassègue B, Williams HC, Faidley EA, Benavides GA, et al. (February 2018). "Poldip2 is an oxygen-sensitive protein that controls PDH and αKGDH lipoylation and activation to support metabolic adaptation in hypoxia and cancer". Proceedings of the National Academy of Sciences of the United States of America. 115 (8): 1789–1794. Bibcode:2018PNAS..115.1789P. doi:10.1073/pnas.1720693115. PMC 5828627. PMID 29434038.

Further reading


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