POLR2J2

POLR2J2

POLR2J2

Protein-coding gene in the species Homo sapiens

DNA directed RNA polymerase II polypeptide J-related gene, also known as POLR2J2, is a human gene.[3]

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This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J.

Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo.[3]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000228049 – Ensembl, May 2017
  2. [2]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. [3]
    "Entrez Gene: POLR2J2 DNA directed RNA polymerase II polypeptide J-related gene".

Further reading


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