DNA-directed RNA polymerases I, II, and III subunit RPABC5 is a protein that in humans is encoded by the POLR2L gene.^[5]

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POLR2L
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5FLM, 5IYD, 5IYC, 5IY8, 5IYA, 5IYB, 5IY6, 5IY9, 5IY7
Identifiers
Aliases	POLR2L, RBP10, RPABC5, RPB10, RPB10beta, RPB7.6, hRPB7.6, polymerase (RNA) II subunit L, RNA polymerase II subunit L, RNA polymerase II, I and III subunit L
External IDs	OMIM: 601189 MGI: 1913741 HomoloGene: 129854 GeneCards: POLR2L
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11p15.5 Start 837,356 bp[1] End 842,529 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 F5 Start 141,051,773 bp[2] End 141,055,045 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle left ventricle abdominal fat biceps brachii right adrenal gland body of pancreas left adrenal gland stromal cell of endometrium thoracic diaphragm retinal pigment epithelium Top expressed in morula proximal tubule adrenal gland lens bone marrow yolk sac white adipose tissue muscle tissue quadriceps femoris muscle neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding zinc ion binding RNA polymerase II activity metal ion binding RNA polymerase III activity DNA-directed 5'-3' RNA polymerase activity protein binding RNA polymerase I activity Cellular component cytosol nucleoplasm RNA polymerase I complex RNA polymerase III complex RNA polymerase II, core complex nucleus Biological process termination of RNA polymerase I transcription mRNA splicing, via spliceosome epigenetic maintenance of chromatin in transcription-competent conformation regulation of transcription by RNA polymerase I transcription initiation from RNA polymerase I promoter transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter fibroblast growth factor receptor signaling pathway transcription by RNA polymerase III snRNA transcription by RNA polymerase II RNA metabolic process regulation of gene silencing by miRNA transcription, DNA-templated transcription elongation from RNA polymerase I promoter positive regulation of type I interferon production somatic stem cell population maintenance positive regulation of viral transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5441 66491 Ensembl ENSG00000177700 ENSMUSG00000038489 UniProt P62875 P62876 RefSeq (mRNA) NM_021128 NM_025593 RefSeq (protein) NP_066951 NP_079869 Location (UCSC) Chr 11: 0.84 – 0.84 Mb Chr 7: 141.05 – 141.06 Mb PubMed search [3] [4]
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This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases.^[6]

POLR2L has been shown to interact with POLR2C,^[7] POLR2A,^[7] POLR2B^[7] and POLR2E.^[7]