Dijon

Born in Langon, Gironde, Lees-Melou started his career with Lège-Cap-Ferret [fr] in the Championnat de France Amateur 2 before sealing a move to Dijon in 2015. He played 16 games (split equally between starts and substitute appearances) as they earned promotion from Ligue 2 in his first season, while also playing in the fifth division with the reserve team. He scored his first two professional goals in April in wins over Clermont and Paris FC, and assisted the opening goal against Ajaccio that earned promotion on the final day.^[2]

In the 2016–17 Ligue 1, Lees-Melou scored 7 goals in 32 games as the team survived in 16th place. On 27 August, he came off the bench to score the final goal of a 4–2 comeback win at home to Lyon.^[2]

Nice

In June 2017, Lees-Melou signed a four-year deal with Nice, worth around €5 million.^[3] He made his debut on 26 July, starting in the third qualifying round of the UEFA Champions League, a 1–1 home draw with Ajax.^[4] After being eliminated in the play-offs by Napoli, the team competed in the UEFA Europa League, and he played all but one game in a run to the last 32.^[2]

In September 2020, having played over 100 games for Nice, Lees-Melou's contract was extended for one year.^[5] His four season-stay ended with 140 games and 18 goals.^[2]

Norwich City

On 13 July 2021, Lees-Melou signed a three-year deal with Norwich City for a fee of under £6 million, ahead of the team's return to the Premier League.^[6] He scored his first goal the following 10 April, opening a 2–0 home win over relegation rivals Burnley; after the game, striker Teemu Pukki said that he would be crucial for the rest of the season.^[7]

Brest

On 23 July 2022, Lees-Melou signed for Ligue 1 side Brest on a three-year contract with an option for a further year. Norwich City received a reported €2.3 million transfer fee and a 10% sell-on clause.^[8]