Polyprenol_reductase

Polyprenol reductase

Polyprenol reductase

Class of enzymes

Polyprenol reductase (EC 1.3.1.94, SRD5A3 (gene), DFG10 (gene)) is an enzyme with systematic name ditrans,polycis-dolichol:NADP+ 2,3-oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

ditrans, polycis-dolichol + NADP+ ditrans, polycis-polyprenol + NADPH + H+
Quick Facts Identifiers, EC no. ...

The reaction occurs in the reverse direction.

See also

References

  1. [1]
    Sagami H, Kurisaki A, Ogura K (May 1993). "Formation of dolichol from dehydrodolichol is catalyzed by NADPH-dependent reductase localized in microsomes of rat liver". The Journal of Biological Chemistry. 268 (14): 10109–13. PMID 8486680.
  2. [2]
    Cantagrel V, Lefeber DJ, Ng BG, Guan Z, Silhavy JL, Bielas SL, Lehle L, Hombauer H, Adamowicz M, Swiezewska E, De Brouwer AP, Blümel P, Sykut-Cegielska J, Houliston S, Swistun D, Ali BR, Dobyns WB, Babovic-Vuksanovic D, van Bokhoven H, Wevers RA, Raetz CR, Freeze HH, Morava E, Al-Gazali L, Gleeson JG (July 2010). "SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder". Cell. 142 (2): 203–17. doi:10.1016/j.cell.2010.06.001. PMC 2940322. PMID 20637498.
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