In chemistry, a protic solvent is a solvent that has a hydrogen atom bound to an oxygen (as in a hydroxyl group −OH), a nitrogen (as in an amine group −NH₂ or −NH−), or fluoride (as in hydrogen fluoride). In general terms, any solvent that contains a labile H⁺ is called a protic solvent. The molecules of such solvents readily donate protons (H⁺) to solutes, often via hydrogen bonding. Water is the most common protic solvent. Conversely, polar aprotic solvents cannot donate protons but still have the ability to dissolve many salts.^[1][2]

Methods for purification of common solvents are available^[3]

• Autoprotolysis