Retinoblastoma-like_protein_1

Retinoblastoma-like protein 1

Retinoblastoma-like protein 1

Mammalian protein found in Homo sapiens

Retinoblastoma-like 1 (p107), also known as RBL1, is a protein that in humans is encoded by the RBL1 gene.[5][6]

Quick Facts RBL1, Available structures ...

Function

The protein encoded by this gene is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 Large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene.[5]

Interactions

Retinoblastoma-like protein 1 has been shown to interact with:

See also

References

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    GRCh38: Ensembl release 89: ENSG00000080839 – Ensembl, May 2017
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    "Entrez Gene: RBL1 retinoblastoma-like 1 (p107)".
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    Chen CR, Kang Y, Siegel PM, Massagué J (Jul 2002). "E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression". Cell. 110 (1): 19–32. doi:10.1016/s0092-8674(02)00801-2. PMID 12150994. S2CID 8945574.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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