Ribonucleoside-triphosphate_reductase

Ribonucleoside-triphosphate reductase

Ribonucleoside-triphosphate reductase

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Ribonucleoside-triphosphate reductase (EC 1.17.4.2, ribonucleotide reductase, 2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase) is an enzyme with systematic name 2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction

2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O ribonucleoside triphosphate + thioredoxin
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Ribonucleoside-triphosphate reductase requires a cobamide coenzyme and ATP.

References

  1. [1]
    Blakley RL (May 1965). "Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of Lactobacillus leichmannii". The Journal of Biological Chemistry. 240: 2173–80. PMID 14299643.
  2. [2]
    Goulian M, Beck WS (September 1966). "Purification and properties of cobamide-dependent ribonucleotide reductase from Lactobacillus leichmannii". The Journal of Biological Chemistry. 241 (18): 4233–42. PMID 5924645.
  3. [3]
    Lammers, M.; Follmann, H. (1983). "The ribonucleotide reductases - a unique group of metalloenzymes essential for cell-proliferation". Struct. Bonding. 54: 27–91. doi:10.1007/bfb0111318.
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