The Archdiocese of Santa Fe de la Vera Cruz (Latin: Archidioecesis Sanctae Fidei Verae Crucis is a Latin Church ecclesiastical jurisdiction or archdiocese of the Catholic Church in Argentina. A metropolitan see, there are two suffragan sees in its ecclesiastical province: Rafaela and Reconquista.

On 15 February 1897 Pope Leo XII founded the Diocese of Santa Fe from territory taken from the Diocese of Paraná. On 20 April 1934 the diocese was elevated to an archdiocese by Pope Pius XI. On the same date it lost territory to create the dioceses of Diocese of Mendoza. It lost further territory when the dioceses of Resistencia (1939), Reconquista (1957) and Rafaela (1961) were created. Blessed John Paul II changed the name of the archdiocese to the Archdiocese of Santa Fe de la Vera Cruz on 19 September 1992.^[1][2] The archdiocese has also had a history of sex abuse allegations, with one recently resulting in current bishop Sergio Fenoy being criminally charged in July 2020 for attempting to supplant an investigation.^[3]