S-1226
S-1226
A novel bronchodilator formulation for the treatment of respiratory diseases.
S-1226, or S1226, is a mixture of carbon dioxide-enriched air and nebulized perflubron being developed as a novel bronchodilator for use in respiratory diseases such as asthma,[1] cystic fibrosis,[2] and COVID-19[3] by SolAeroMed.
Unlike typical bronchodilators such as β2-adrenergic agonists and antimuscarinics, S-1226 does not act on receptors in the airways. Instead, it combines the bronchodilator activity of gaseous carbon dioxide with the mucolytic properties of the synthetic surfactant perflubron to relax the smooth musculature of the airways, clear excess mucus, and reduce inflammation. Thus, S-1226 represents a novel class of bronchodilators that could alleviate certain problems of existing therapeutics, such as the buildup of tolerance to their effects and their inefficient penetration of airway mucus.[1][4]