SPTBN5

SPTBN5

SPTBN5

Protein-coding gene in the species Homo sapiens

Spectrin, beta, non-erythrocytic 5 also known as SPTBN5 is a protein that in humans is encoded by the SPTBN5 gene.[5] SPTBN5 belongs to the spectrin family of cytoskeletal proteins.

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Structure and function

SPTBN5 contains the following domains:[5]

Based on these structural features it is thought that SPTBN5 is likely to form heterodimers and oligomers with alpha-spectrin and to interact directly with cellular membranes.[5]

SPTBN5 is highly expressed in embryoid bodies.[6]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000137877 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000074899 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Stabach PR, Morrow JS (July 2000). "Identification and characterization of beta V spectrin, a mammalian ortholog of Drosophila beta H spectrin". J. Biol. Chem. 275 (28): 21385–95. doi:10.1074/jbc.C000159200. PMID 10764729.
  6. [6]
    Chaerkady R, Kerr CL, Marimuthu A, Kelkar DS, Kashyap MK, Gucek M, Gearhart JD, Pandey A (January 2009). "Temporal analysis of neural differentiation using quantitative proteomics". J. Proteome Res. 8 (3): 1315–26. doi:10.1021/pr8006667. PMC 2693473. PMID 19173612.

Further reading


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