Samuel Cook may refer to:

• Samuel Cook (artist) (1806–1859), English watercolour painter
• Samuel Cook (Chartist) (1786–1861)
• Samuel A. Cook (1849–1918), U.S. Representative from Wisconsin
• Samuel Albert Cook (1878–1915), medical doctor and member of the American Red Cross mission in Serbia
• Sam C. Cook (1855–1924), Mississippi Supreme Court justice
• Samuel DuBois Cook (1928–2017), political scientist and professor
• Samuel E. Cook (1860–1946), U.S. Representative from Indiana
• Samuel Edward Cook (1787–1856), English writer
• Samuel Edward-Cook, English actor
• Samuel H. Cook, United States Army officer of the Civil War
• J. Samuel Cook (born 1983), African-American playwright, journalist and writer

• Sam Cook (disambiguation)
• Samuel Cooke (disambiguation)
• Cook (surname)

This disambiguation page lists articles about people with the same name.
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