Santo Domingo de los Colorados,^[3] often simply referred to as Santo Domingo (Quechua: Tsachila), is an Ecuadorian city and seat of the canton that bears its name and the Santo Domingo de los Tsáchilas Province. It is the fourth most populous city in Ecuador, with a population of 334,826, and is an important commercial and industrial center.^[4]

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Santo Domingo
City
From top, left to right: Panoramic view of Santo Domingo, Cathedral of the Ascension of the Lord, City hall of Santo Domingo, monument to the Settler, Zaracay Park, Vista Hermosa Towers, Bomboli hill and Sanctuary of Holy Mary de Bomboli.
Santo Domingo
Coordinates: 00°15′15″S 79°10′19″W[1]
Country	Ecuador
Province	Santo Domingo de los Tsáchilas
Canton	Santo Domingo
Created	May 29, 1861
Named for	Los Colorados, Jesus
Urban Parishes	List of parishes Abraham Calazacón Bomboli Chiguilpe Río Toachi Río Verde Los Colorados Zaracay
Government
• Mayor	Wilson Erazo Argoti
Area
• City	67.14 km2 (25.92 sq mi)
• Canton	3,454 km2 (1,334 sq mi)
Elevation	625 m (2,051 ft)
Population  (2022 census)[2]
• City	334,826
• Density	5,000/km2 (13,000/sq mi)
• Canton	441,583
• Canton density	130/km2 (330/sq mi)
Demonym	Santodomingueño
Area code	(+593) 02
Climate	Tropical monsoon and humid
Website	www.santodomingo.gov.ec/ (in Spanish)

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The name, "de los Colorados", refers to a local ethnic group, the Tsáchila, and the custom of men in that tribe to dye their hair with extract of the achiote plant; hence "Santo Dominigo de los Colorados" or "Santo Domingo of the Dyed." This group, which is indigenous to the area, is recognised with a substantial statue near the town center.^{[citation needed]}

Santo Domingo is located approximately 133 km west of Quito at an elevation of 625 m. Santo Domingo lies in the foothills west of the Andes. It is important stopping point on the road from Quito to the Pacific coast. The city also connects other lowland cities like Quevedo, Chone, and Quinindé.

The city is also the seat of the Roman Catholic Diocese of Santo Domingo de los Colorados.