2010

Redding signed with new team Marc VDS Racing Team in the Moto2 600cc class for 2010,^[14] having grown too big to continue competing in the 125cc class.^[15] He struggled in the initial pre-season tests, but was more competitive in later ones.^[16] Redding struggled at the beginning of the season, but improved to finish fourth in the British Grand Prix at Silverstone and became the youngest rider ever to score a podium finish in the 250cc/Moto2 class by finishing third in Indianapolis.^[17]

At the San Marino Grand Prix in Misano, Redding was involved in an accident which resulted in the death of Japanese rider Shoya Tomizawa. After Tomizawa fell from his bike on the twelfth lap of the race, he was immediately hit by Redding and Alex de Angelis, who were unable to avoid him. Redding received ten stitches for a back laceration but escaped major injury.^[18]

On 29 September 2010, Redding signed a two-year contract with Marc VDS, keeping him in Moto2 until 2012.^[19]

2011

Redding finished the season in 15th place with 63 points, with a best result of fifth place, obtained on three occasions: at Silverstone, Indianapolis and Misano.

2012

Redding finished the season in fifth position, having collected 165 points, a second place in the 2012 British motorcycle Grand Prix, his home race, along with four other podiums, all third places finishes.

2013

Riding again for Marc VDS, Redding finished a close second in the championship after a season-long battle against Pol Espargaró. During the season, Redding obtained three victories, three second places, a third place, and three pole-positions. With three races left in the season he held a lead of 10 points over Espargaró; however, Redding crashed during qualifying in Australia, fracturing his wrist and could not participate in the race.^[20] Pol Espargaró won the race. In the following Japanese Grand Prix, Redding collided with the motorcycle of Esteve Rabat who had crashed in front of him in the second turn of the race. The race was red-flagged and restarted without an injured Redding; this second incident took him out of contention for the title, which Espargaró won by winning the Japanese race too.^[21]

2014

Redding switched to MotoGP with the GO & FUN Gresini team on a Honda RCV1000R production racer, his teammate was Álvaro Bautista. He was consistent over the year, finishing every race except Austin. His best results of the season were two seventh-place finishes, at the season-opening round in Qatar and at Phillip Island. He finished 12th in the championship, scoring 81 points. He was also runner-up in the "open class" category, albeit 45 points behind Aleix Espargaró.

2015

In 2015 Redding remained in MotoGP, re-joining his former team Marc VDS. He was riding a factory-specification Honda RC213V. At the San Marino Grand Prix, Redding achieved his maiden MotoGP podium with a third-place finish despite crashing early in the race.^[22] With Bradley Smith finishing second, the duo became the first pair of British riders to finish on a premier class podium since Barry Sheene and Tom Herron did so at the Venezuelan Grand Prix in 1979.^[23] On 30 August 2015, the morning of his home race at Silverstone, it was announced that Redding would join Pramac Racing for the 2016 season, replacing Yonny Hernández alongside Danilo Petrucci.^[24]

2016

Scott Redding remained in MotoGP for his third season, this time racing for Pramac Racing, his third team in three seasons. Riding on a Ducati Desmosedici GP15, with fellow teammate Danilo Petrucci, Scott Redding had a mixed season. He only finished 15th in the standings, one point behind Petrucci, but he managed to get his second, and to date his last, MotoGP podium at the 2016 Dutch TT.

2017

In 2017, Redding stayed with Pramac Racing Ducati, together with Danilo Petrucci. However, due to last years performances, Danilo Petrucci received a GP17 Ducati Desmosedici with factory support while Redding had to do with the GP16. During this year, Petrucci emerged as the far stronger rider with Redding never finishing higher than seventh in both Qatar and San Marino. In turn, this would be his last year with Pramac Racing.

2018

After his contract at Ducati was not extended, Redding signed with Aprilia for the 2018 season. He replaced fellow british rider Sam Lowes, who had a catastrophic 2017 season, finishing with just 5 points, compared to teammate Aleix Espargaró's 62. The 2018 season did not go as planned for Aprilia however, Espargaró finished with 44 points, and a best result of 6th in Aragon, while Redding finished with 20 points, and not having a top 10 finish all year. Following the season, Redding was not re-signed by the team.

2019

In 2019, he competed in the British Superbike Championship riding a Ducati Panigale V4 for Paul Bird's PBM team.^[25] He won the championship on his first attempt, after an epic showdown with his teammate Josh Brookes, Redding edging him out by a mere 5 points, over a 27 race season.^[26]

2020

For 2020, Redding competed in the Superbike World Championship, signing a two-year deal to ride a factory Ducati Panigale V4 for the Aruba.it Racing team.^[27] He had a successful first season, finishing on the podium 13 times in 24 races (5 times first, 5 times second, 3 times in third place), and finished second overall in the standings.

2021

As of late season 2021, Redding already has 6 victories, 9 second place finishes, 4 third place finishes, and is third in the standings currently. In August, he and BMW announced that Redding would switch from Ducati to BMW for 2022, a move that surprised many people.^[28]