Seantrel Henderson (born January 21, 1992^[1][2]) is an American football offensive tackle who is a free agent. He was drafted by the Buffalo Bills in the seventh round of the 2014 NFL draft. He played college football at the University of Miami.

Henderson attended Cretin-Derham Hall High School and originally signed a letter of intent to play college football at the University of Southern California,^[3] but was granted release from his commitment by Coach Lane Kiffin in July 2010 and eventually committed to the University of Miami.^[4]

Henderson was considered the top overall player in his class by a number of recruiting services; Rivals.com named him their 2008 Junior of the Year,^[5] while USA Today named him to their All-American First-Team as one of only two juniors.^[6] Henderson made the All-USA team in 2009 again, and was also named Offensive Player of the Year, the first lineman to do so in the 28-year history of the award.^[7] Tom Lemming called him "a cross between Jonathan Ogden and Orlando Pace," two of the best offensive tackles in the NFL in the 2000s;^[8] Sports Illustrated called him "probably the most polished lineman of the past decade".^[9]

He was also featured in a July 2008 issue of Sports Illustrated, profiling young athletes poised to star in their sports, alongside Taylor Hall and Jeremy Tyler.^[10]

In 2009, Henderson helped Cretin-Derham Hall to a 5A state championship and was named Minnesota Player of the Year by the Associated Press. It's believed to be the first time the annual award has gone to a lineman.^[11]

A two-sport star, Henderson also played basketball.^[1] He played for the "Howard Pulley Panthers" on the AAU circuit alongside Harrison Barnes, one of the nation's top basketball prospects.^[12] Henderson also threw shot put and discus and won the 1,500 meter race walk, shot put, and discus in the USATF 2004 Minnesota Junior Olympics Outdoor Championships.

As a true freshman at Miami, Henderson played 12 games (including 9 starts) and saw most of his action at right tackle. Henderson earned All-Freshman selections by the Football Writers Association of America, College Football News, Phil Steele, and Rivals.com.^[18][19]

In 2011, Henderson played in eight games and earned two starts after recovering from off-season back surgery. In March 2012, Henderson was suspended for the first weekend of spring practice for violating team policy. The team also announced that he would not play in the opening game of the 2012 season against Maryland.^[20][21]

On August 1, 2012, Henderson was involved in a car accident while driving to a friend's funeral in which the Chevy Impala he was driving ran a red light and crashed into a car carrying a family of six. Two children in the car were transported to the hospital. Henderson received a concussion. Henderson was cited for driving with an expired license and running a red light. Henderson missed the first twelve Miami Hurricane practices while recovering from the concussion.^[22]

In the 2012 season, Henderson started seven games at right tackle for the Hurricanes.^[23] He was an honorable mention on the All-Atlantic Coast Conference team. Henderson opted to remain at Miami rather than make himself eligible for the 2013 NFL draft.^[24]

After the 2013 season, Henderson was once again named an honorable mention on the All-Atlantic Coast Conference team.^[25] He was demoted to backup for three games and suspended for one.^[26]

Henderson was invited to the 2014 Senior Bowl. Before the game, he admitted that marijuana use led to his three suspensions from the University of Miami football team. "I'm just being honest with every (NFL) team and letting them know exactly what the situations were, and that I'm putting all the negative things behind me moving on to the next level," he said. "I want to be a starter and play in the NFL."^[27]